Scientists have found a vital information about Insulin, the essence of life force. Presence of less insulin, the glucose-regulating hormone, in brain may be the cause for long life. This tremendous information is reported in the journal “Science” by a group of researchers headed by Dr. Morris White, a Howard Hughes Institute investigator at Children’s Hospital in Boston, USA. The group picked up mutant mice that over-ate, became fat and got symptoms of diabetes but yet lived 18% longer than their normal lab nice. The secret behind this is that these mice lacked a key gene that affects insulin. This new information raises question about how desirable it is to use insulin for treating type-2 diabetes. It is known to the Doctors that people doing exercise regularly live longer on average. The researchers also know that putting animals on a strict diet makes them live longer, though this has not been shown to work in human beings. So, Dr. Morris White’s group wanted to see if the two effects were linked. They had looked at Insulin because both fasting and exercise make cells more insulin-sensitive, meaning they respond more effectively to the effects of insulin.
The group made effort to look at the entire insulin pathway-a series of actions in the cell that control the body’s use of insulin. The team investigated mice that had no working copies of one of the genes involved in this pathway, called insulin receptor substrate 2 or Irs2. The group found that mice with no copies of Irs2 got defective brains and also diabetes. But mice having one working copy lived 18% longer than normal lab mice even if they could shorten their lives being overweight and having higher insulin levels in their blood. Read more…
